The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans.
Kevin O'GallagherRyan E RosentreterJan Elaine SorianoAli RoomiSaqib SaleemTyler LamRoman RoyGrant R GordonSatish R RajPhillip J ChowienczykAjay M ShahAaron A PhillipsPublished in: Circulation research (2022)
Neuronal NOS plays a role in dynamic cerebral blood flow control in healthy adults, particularly the rapidity of the NVC response to visual stimulation. This work opens the way to further investigation of the role of nNOS in conditions of impaired NVC, potentially revealing a therapeutic target.