Novel Gene-Modified Mesenchymal Stem Cell Therapy Reverses Impaired Wound Healing in Ischemic Limbs.

Carlos Theodore HuertaYulexi Y OrtizYan LiAntoine J RibierasFrancesca VozaNga LeCaroline DodsonGaofeng WangRoberto I Vazquez-PadronZhao-Jun LiuOmaida C Velazquez

Published in: Annals of surgery (2023)

We establish a novel method to potentiate regenerative and pro-angiogenic capability of MSCs by modification with E-selectin/AAV. This innovative therapy carries potential as a platform worthy of future clinical studies.

Keyphrases

mesenchymal stem cells
stem cells
wound healing
cell therapy
umbilical cord
bone marrow
genome wide
transcription factor
risk assessment
tissue engineering
gene expression
high throughput
smoking cessation
blood brain barrier
gene therapy
human health
subarachnoid hemorrhage
replacement therapy