Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation.

Eun-Jin YunChung-Jung LinAndrew DangElizabeth HernandezJia-Ming GuoWei-Min ChenJoyce AllisonNathan KimPayal KapurJames BrugarolasKaijie WuDalin HeChih-Ho LaiDebabrata SahaSeung Tae BaekBenjamin P C ChenJer-Tsong Hsieh

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

In this study, we unveil that loss of DAB2IP resulted in elevated PARP-1 protein is associated with IR-resistance in RCC. These results provide a new targeting strategy to improve the efficacy of radiotherapy of RCC.

Keyphrases

renal cell carcinoma
gene expression
endothelial cells
early stage
dna methylation
dna damage
signaling pathway
radiation therapy
cell proliferation
dna repair
radiation induced
locally advanced
amino acid
squamous cell carcinoma
small molecule