Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Roux-en-Y Gastric Bypass Outcomes: a 15-Year Case-Control Study.
Alejandro CamposLizeth CifuentesAnas HashemBradley BusebeeMaria D Hurtado-AndradeMaria L Ricardo-SilgadoAlison McRaeAlan De la RosaFauzi FerisJoshua T BublitzDonald HensrudMichael CamilleriTodd A KelloggJeanette E Eckel-PassowJanet OlsonAndres AcostaPublished in: Obesity surgery (2022)
Carriers of a heterozygous variant in the leptin-melanocortin pathway have a progressive and significant weight regain in the mid- and long-term after RYGB. Genotyping patients experiencing significant weight regain after RYGB could help implement multidisciplinary and individualized weight loss interventions to improve weight maintenance after surgery.
Keyphrases
- roux en y gastric bypass
- weight loss
- gastric bypass
- bariatric surgery
- glycemic control
- end stage renal disease
- obese patients
- early onset
- weight gain
- physical activity
- newly diagnosed
- ejection fraction
- body mass index
- peritoneal dialysis
- multiple sclerosis
- genome wide
- copy number
- type diabetes
- patient reported outcomes
- high throughput
- dna methylation
- skeletal muscle
- quality improvement
- genetic diversity