Risk of second primary malignancies associated with radiotherapy in prostate cancer patients: competing risk analysis.
Yijun WuYunlong LiChang HanYuming ChongKai KangZhikai LiuFuquan ZhangPublished in: Future oncology (London, England) (2022)
Background: The effect of radiotherapy (RT) for second primary malignancies (SPMs) among prostate cancer survivors is controversial. Methods: Applying logistic regression, competing risk analysis and propensity score matching method, this study analyzed clinical data from the Surveillance, Epidemiology, and End Results program to compare the risk for SPMs between patients receiving RT and non-RT. Results: In this study, prostate cancer patients treated with RT developed more SPMs in the anus, bladder, rectum, liver, lung and bronchus and lymphoma than non-RT groups. Conclusion: More intensive surveillance should be adopted for these cancers among prostate cancer survivors.
Keyphrases
- prostate cancer
- radical prostatectomy
- public health
- end stage renal disease
- early stage
- young adults
- ejection fraction
- radiation therapy
- chronic kidney disease
- spinal cord injury
- squamous cell carcinoma
- locally advanced
- radiation induced
- quality improvement
- prognostic factors
- benign prostatic hyperplasia
- childhood cancer
- patient reported outcomes