[Influences of human dermis derived mesenchymal stem cells on α-SMA and DCN expressions of hypertrophic scars fibroblasts].

Wenduo ZhangChengliang DengChangmin GuoKaiyu NieXiujun TangZairong WeiDali Wang

Published in: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery (2018)

hDMSCs can down-regulate α-SMA mRNA and protein expressions of HSFBs and up-regulate mRNA and protein expressions of DCN in the in-vitro culture system.Those effects were particularly obvious on fibroblasts at the early formation of hyperplastic scar.Anti fibrosis role of hDMSCs is expected to be used in increasing the healing quality of the wound and in the prevention and treatment of pathological scars.

Keyphrases

binding protein
endothelial cells
protein protein
extracellular matrix
platelet rich plasma
amino acid
combination therapy
replacement therapy
smoking cessation