Prophylactic Pulmonary Artery Banding in Pediatric Dilated Cardiomyopathy: An Additional Therapeutic Option.
Elena PanaioliDiala KraicheMargaux PontaillerFlavie AderOlivier RaiskyRegis GaudinDamien BonnetPublished in: Journal of cardiovascular development and disease (2024)
Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with considerable early mortality. Heart transplantation is often the only viable life-saving option. Pulmonary artery banding (PAB) has been recently proposed as a bridge or alternative to transplantation for DCM. In our cohort, PAB was selectively addressed to heritable DCM or DCM with congenital left ventricle aneurysm (CLVA). This study aimed to describe the clinical evolution and left ventricle reverse remodeling (LVRR) over time (6 months and 1 year after surgery). Ten patients with severe DCM received PAB between 2016 and 2021 and underwent clinical and postoperative echocardiography follow-ups. The median age at PAB was <1 year. The in-hospital mortality was zero. Two patients died two months after PAB of end-stage heart failure. The modified Ross class was improved in the eight survivors with DCM and remained stable in the two patients with CLVA. We observed a positive LVRR (LV end-diastolic diameter Z-score: 8.4 ± 3.7 vs. 2.8 ± 3; p < 0.05; LV ejection fraction: 23.8 ± 5.8 to 44.5 ± 13.1 ( p < 0.05)). PAB might be useful as part of the armamentarium available in infants and toddlers with severe DCM not sufficiently responding to medical treatment with limited probability of spontaneous recovery.
Keyphrases
- congenital heart disease
- pulmonary artery
- ejection fraction
- coronary artery
- pulmonary hypertension
- pulmonary arterial hypertension
- heart failure
- aortic stenosis
- left ventricular
- healthcare
- early onset
- computed tomography
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- blood pressure
- risk factors
- cardiovascular disease
- type diabetes
- stem cells
- acute heart failure
- early life
- bone marrow