Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats.
Danielle DantasAmanda Gomes PereiraAnderson Seiji Soares FujimoriAna Paula Dantas RibeiroCarol Cristina Vágula de Almeida SilvaMarina Gaiato MonteCamila Renata CorrêaAna Angélica FernandesSilmeia Garcia Zanati BazanPaula Schmidt AzevedoMarcos Ferreira MinicucciSergio Alberto Rupp de PaivaLeonardo Antônio Mamede ZornoffBertha Furlan PolegatoPublished in: Journal of cardiovascular development and disease (2022)
Doxorubicin increases oxidative stress and promotes changes in myocardial energy metabolism, accompanied by structural and functional changes. Doxycycline attenuated the doxorubicin-induced cardiotoxicity, at least in part, through changes in myocardial energy metabolism.