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Statistical Analysis of Clinical COVID-19 Data: A Concise Overview of Lessons Learned, Common Errors and How to Avoid Them.

Martin WolkewitzJerome LambertMaja Katharina von CubeLars BugieraMarlon GroddDerek HazardNicole M WhiteAdrian Gerard BarnettKlaus Kaier
Published in: Clinical epidemiology (2020)
By definition, in-hospital patient data are restricted to the time between hospital admission and discharge (alive or dead). For hospitalised cases of COVID-19, a number of events during hospitalization are of interest regarding the influence of risk factors on the likelihood of experiencing these events. The same is true for predicting times from hospital admission of COVID-19 patients to intensive care or from start of ventilation (invasive or non-invasive) to extubation. This logical restriction of the data to the period of hospitalisation is associated with a substantial risk that inappropriate methods are used for analysis. Here, we briefly discuss the most common types of bias which can occur when analysing in-hospital COVID-19 data.
Keyphrases
  • sars cov
  • coronavirus disease
  • electronic health record
  • adverse drug
  • healthcare
  • risk factors
  • big data
  • acute care
  • data analysis
  • respiratory syndrome coronavirus
  • machine learning
  • mechanical ventilation
  • drug induced