Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis.

Samin HajianMehrdokht MazdehFatemeh NouriGhodratollah RoshanaeiMeysam Soleimani

Published in: Molecular biology reports (2021)

The present study results suggest that the genetic heterogeneity in the promoter region of IFNAR1 could affect the response to IFN-β. However, further studies with a larger sample size are needed to further demonstrate this relationship.

Keyphrases

dendritic cells
dna methylation
gene expression
genome wide
transcription factor
copy number
single cell
binding protein
genome wide identification
case control