Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium.
Inga Baasch ChristensenQi WuAnders Solitander BohlbroMarianne Gerberg SkalsHelle Hasager DamkierChristian Andreas HübnerRobert Andrew FentonJeppe PraetoriusPublished in: Fluids and barriers of the CNS (2020)
Our findings suggest that the lack of effective Na+-entry into the epithelial cells of the choroid plexus leads to a profound change in the cellular phenotype, shifting from a high-rate secretory function towards a more dormant state; similar to what is observed during ageing or Alzheimer's disease.