Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells.
Sefa ArlierUmit Ali KayisliAydın ArıcıPublished in: Turkish journal of obstetrics and gynecology (2018)
Our results support the conclusion that one pathway for estradiol-mediated NF-кB inhibition occurs through the down-regulation of IкB phosphorylation. We propose that the estradiol-induced regulation of IкB and consequent reduction in active-NF-кB may affect inflammatory responses in human endometrial cells.
Keyphrases
- induced apoptosis
- signaling pathway
- nuclear factor
- cell cycle arrest
- high glucose
- endothelial cells
- oxidative stress
- diabetic rats
- pi k akt
- estrogen receptor
- lps induced
- endoplasmic reticulum stress
- rheumatoid arthritis
- drug induced
- endometrial cancer
- protein kinase
- replacement therapy
- cell proliferation
- induced pluripotent stem cells