Iron-sensitive MR imaging of the primary motor cortex to differentiate hereditary spastic paraplegia from other motor neuron diseases.
Mirco CosottiniGraziella DonatelliIvana RiccaFrancesca BianchiDaniela FrosiniVincenzo MontanoGianmichele MigaledduEleonora Del PreteAlessandra TessaPaolo CecchiClaudio D'AmelioGabriele SicilianoMichelangelo MancusoFilippo Maria SantorelliPublished in: European radiology (2022)
• The T2* signal intensity of the primary motor cortex was investigated in patients with HSP, PLS with lower limb onset, and ALS with lower limb and prevalent UMN onset (UMN-ALS) using a clinical 3-T MRI sequence. • Most HSP patients had normal signal intensity in the primary motor cortex (86%); on the contrary, all the PLS and the majority of UMN-ALS patients (75%) had marked cortical hypointensity. • The T2*-weighted imaging of the primary motor cortex could provide useful information in the differential diagnosis of sporadic adult-onset UMN syndromes.
Keyphrases
- lower limb
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- amyotrophic lateral sclerosis
- peritoneal dialysis
- prognostic factors
- magnetic resonance imaging
- high resolution
- healthcare
- magnetic resonance
- high intensity
- heat shock protein
- heat stress
- computed tomography
- heat shock
- early onset
- fluorescence imaging
- diffusion weighted imaging