Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.

Hui ChengJie DingGusheng TangAijie HuangLei GaoJian-Min Yang Li Chen

Published in: Molecular medicine (Cambridge, Mass.) (2021)

TRIM14 could promote the proliferation of AML cells via activating PI3K/AKT pathway, which was reversed by HMSC-exos through delivering miR-23b-5p. These findings indicated that miR-23b-5p and TRIM14 could be applied as potential targets for the treatment of AML.

Keyphrases

acute myeloid leukemia
mesenchymal stem cells
induced apoptosis
signaling pathway
cell cycle arrest
endothelial cells
allogeneic hematopoietic stem cell transplantation
stem cells
umbilical cord
endoplasmic reticulum stress
cell death
bone marrow
climate change