Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.

Shan-Ying WuSheng-Hui LanShang-Rung WuYen-Chi ChiuXi-Zhang LinIh-Jen SuTing-Fen TsaiChia-Jui YenTsung-Hsueh LuFu-Wen LiangChung-Yi LiHuey-Jen SuChun-Li SuHsiao-Sheng Liu

Published in: Hepatology (Baltimore, Md.) (2018)

Taken together, our data demonstrate that autophagic degradation machinery and the cell-cycle regulator, cyclin D1, are linked to HCC tumorigenesis. We believe these findings may be of value in the development of alternative therapeutics for HCC patients. (Hepatology 2018;68:141-154).

Keyphrases

cell cycle
cell proliferation
end stage renal disease
cell death
ejection fraction
chronic kidney disease
newly diagnosed
electronic health record
peritoneal dialysis
prognostic factors
small molecule
oxidative stress
transcription factor
endoplasmic reticulum stress
big data
cell cycle arrest
drug induced