Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy.

Published in: The Journal of cell biology (2023)

In this issue, Hennlein and colleagues (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202204113) show that F-actin-bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and promotes BDNF-TrkB signaling in the growth cones of spinal motor neurons.

Keyphrases

spinal cord
single cell
cell migration
cell proliferation
cell therapy
mouse model
transcription factor
stem cells
protein protein
mesenchymal stem cells
bone marrow