Glioplasticity in irritable bowel syndrome.

N L LilliLucille QuénéhervéS HaddaraCharlène Brochard Aubert Philippe Malvyne Rolli-Derkinderen Tony Durand Philippe Naveilhan Jean-Benoit Hardouin Roberto De Giorgio Giovanni Barbara S Bruley des Varannes Emmanuel Coron Michel Neunlist

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

Changes in EGC occur in IBS, involving mucosal soluble factors. Histamine, via activation of H1R-dependent pathways, partly mediates altered Ca2+ response to ATP in EGC. These changes may contribute to the pathophysiology and the perception of pain and bloating in patients with IBS.

Keyphrases

irritable bowel syndrome
chronic pain
pain management
neuropathic pain
ulcerative colitis
protein kinase