Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies.
Antonio Ji-XuLiam CarrollThomas BentleyRachael JarrettPublished in: BMJ case reports (2022)
Granulocyte colony-stimulating factor (G-CSF) administration is associated with a diverse range of cutaneous sequelae. Serious dermatological side effects of G-CSF include the development of Sweet's syndrome and exacerbations of pre-existing inflammatory disorders such as psoriasis. Here, we describe a report of acute leucocytoclastic vasculitis caused by G-CSF therapy associated with anti-Ro and anti-La antibodies in a patient with multiple myeloma. This case highlights the importance of having a high index of suspicion for acute leucocytoclastic vasculitis in patients with haematological malignancies undergoing G-CSF therapy.
Keyphrases
- liver failure
- respiratory failure
- multiple myeloma
- drug induced
- aortic dissection
- chronic obstructive pulmonary disease
- case report
- oxidative stress
- cystic fibrosis
- peripheral blood
- cerebrospinal fluid
- intensive care unit
- bone marrow
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- smoking cessation
- replacement therapy