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Enhancing the Stability of Nicotine via Crystallization Using Enantiopure Tartaric Acid Salt Formers.

Devin J AngevineKristine Joy CamachoXiaotong ZhangJavid RzayevJason B Benedict
Published in: ACS omega (2023)
Crystallization of nicotine, an oil prone to degradation at room temperature, has been demonstrated to be an effective means of creating nicotine-based materials with tunable thermal properties and improved resistance to photo-induced degradation. Herein, we show that both isomers of enantiomerically pure tartaric acid are highly effective salt formers when combined with nicotine. Both salts exhibit enhanced photostability, and with a melting point of 143.1 °C, the salt prepared using d-(-)-tartaric acid possesses one of the highest melting points for a crystalline nicotine solid reported to date.
Keyphrases
  • smoking cessation
  • room temperature
  • ionic liquid
  • high resolution
  • diabetic rats
  • oxidative stress