Identification of potential immune-related hub genes in Parkinson's disease based on machine learning and development and validation of a diagnostic classification model.

Guanghao XinJingyan NiuQinghua TianYanchi FuLixia ChenTingting YiKuo TianXuesong SunNa WangJianjian WangHuixue Zhang Lihua Wang

Published in: PloS one (2023)

In this study, four immune-related PD hub genes (dld, dlk1, iars and ttd19) were obtained. A reliable diagnostic model for PD classification was developed. This study provides algorithmic-level support to explore the immune-related mechanisms of PD and the prediction of immune-related drug targets.

Keyphrases

machine learning
bioinformatics analysis
deep learning
genome wide
gene expression
risk assessment
transcription factor
climate change
electronic health record
human health