Development of immunity-related adverse events correlates with baseline clinical factors, survival and response to anti-PD-1 treatment in patients with inoperable or metastatic melanoma.
Bozena Cybulska-StopaMarcin ZiętekAnna M CzarneckaKarolina PiejkoRobert DziuraŁukasz GalusBarbara ZiółkowskaStanisław KieszkoNatasza Kempa-KamińskaJacek CalikJoanna SeredyńskaKamila GądekTomasz ZemełkaPaweł TeteryczTomasz KubiatowskiRafał SuwińskiJacek MackiewiczPiotr RutkowskiPublished in: The Journal of dermatological treatment (2021)
The occurrence of irAE was associated with longer OS, PFS, and more frequent response to treatment. IrAE occurred statistically significantly more often in patients with mucosa primary tumor, with normal LDH levels, without brain metastases, stages III, M1a, and M1b.