The risk of anti-osteoporotic agent-induced severe cutaneous adverse drug reactions and their association with HLA.

Chun-Bing ChenY-E ChenM-T ChuC-W WangR C-Y HuiChun-Wei LuY-P HsiaoChia-Yu ChuM M ChangC M-T CheungC-Y ChengY-W WangY-J LinC-J ChangShuen-Iu Hung Wen-Hung Chungnull null

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)

Strontium ranelate is identified as the most notorious AOA associated with SCAR. The HLA-A*33:03 genetic allele and LAT testing may add benefits to the diagnosis of SR-SCAR in patients whose reaction developed while taking multiple drugs.

Keyphrases

adverse drug
end stage renal disease
drug induced
ejection fraction
chronic kidney disease
prognostic factors
emergency department
genome wide
early onset
gene expression
dna methylation
bone mineral density
postmenopausal women
endothelial cells