A longitudinal observational study of aetiology and long-term outcomes of sepsis in Malawi revealing the key role of disseminated tuberculosis.
Joseph M LewisMadlitso MphasaLucy KeyalaRachel BandaEmma L SmithJackie DugganTim BrooksMatthew CattonJane MallewaGrace KathaStephen B GordonBrian FaragherMelita A GordonJamie RylanceNicholas A FeaseyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Sepsis in Blantyre, Malawi, is caused by a range of pathogens; the majority are not susceptible to the broad-spectrum antibacterials that most patients receive. HIV status is a key determinant of aetiology. Novel antimicrobial strategies for sepsis tailored to sSA - including consideration of empiric antitubercular therapy in the HIV-infected - should be developed and trialed.
Keyphrases
- hiv infected
- antiretroviral therapy
- septic shock
- acute kidney injury
- intensive care unit
- end stage renal disease
- hiv aids
- newly diagnosed
- ejection fraction
- chronic kidney disease
- staphylococcus aureus
- mycobacterium tuberculosis
- hepatitis c virus
- prognostic factors
- peritoneal dialysis
- stem cells
- hiv testing
- emergency department
- mesenchymal stem cells
- chemotherapy induced