A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity, and Inflammation.
Arivarasu N AnbazhaganYong GeShubha PriyamvadaAnoop KumarDulari JayawardenaArvind Raj Vishnu PalaniNazim HusainNeelkanth KulkarniShaunik KapoorPrabhdeep KaurApurba MajumderYang-Ding LinLeeany MalettaRavinder K GillWaddah A AlrefaiSeema SaksenaKimia ZadehSungmo HongMansour MohamadzadehPradeep K DudejaPublished in: Gastroenterology (2024)
Our data demonstrate that loss of PAT1 disrupts gut microbiome and related metabolites, decreases gut-barrier integrity, and increases host susceptibility to intestinal inflammation. These findings, thus, highlight a novel role of the oxalate transporter PAT1 in promoting gut-barrier integrity, and its deficiency appears to contribute to the pathogenesis of inflammatory bowel diseases.