Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis.

Alexander SchnellJörg JüngertDaniel KlettHannah HoberNatalie KaiserRenate RuppelAnnika GeppertChristina TremelJulia SobelErika PlattnerSabina Schmitt-GrohéSabine ZirlikDeike StrobelMarkus F NeurathFerdinand KnielingManfred RauhJoachim WoelfleAndré HoerningAdrian P Regensburger

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

ARFI SWV and bile acid profiles provide evidence for early increase in liver stiffness and altered bile acid metabolism in young CF patients after initiation of ETI and may serve as synergistic measures for detection of hepatic complications during ETI therapy.

Keyphrases

young adults
cystic fibrosis
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
risk factors
stem cells
cancer therapy
drug delivery
middle aged
patient reported