Single HER2-positive tumor cells are detected in initially HER2-negative breast carcinomas using the DEPArray™-HER2-FISH workflow.

Lisa GrüntkemeierAditi KhuranaFarideh Zamaniyan BischoffOliver HoffmannRainer KimmigMathew MoorePhilip CotterSabine Kasimir-Bauer

Published in: Breast cancer (Tokyo, Japan) (2022)

The DEPArray™ system allows pure tumor cell recovery for subsequent HER2/neu FISH analysis and is highly concordant with conventional pathology. For PT-HER2-negative patients, harboring HER2/neu-positive CTCs, this approach might allow caregivers to more effectively offer anti-HER2 treatment.

Keyphrases

ejection fraction
newly diagnosed
single cell
circulating tumor cells
high grade
electronic health record
bone marrow
smoking cessation
patient reported