Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep.
Sharmony B KellyVanesa StojanovskaValerie A ZahraAlison MoxhamSuzanne L MillerTimothy J M MossStuart B HooperMarcel F NoldClaudia A Nold-PetryJustin M DeanLaura BennetGraeme R PolglaseAlistair J GunnRobert GalinskyPublished in: Journal of neuroinflammation (2021)
IL-1Ra improved EEG activity and markedly attenuated systemic inflammation, microgliosis and oligodendrocyte loss following LPS exposure in near-term fetal sheep. Further studies examining the long-term effects on brain maturation are now needed.
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