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Diagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in cerebrospinal fluid in pediatric patients with central nervous system infection: a systematic review and meta-analysis.

Sike HeYing XiongTeng TuJiaming FengYu FuXu HuNeng WangDapeng Li
Published in: BMC infectious diseases (2024)
Current evidence shows that mNGS presents a good diagnostic performance in pediatric CNSI. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
Keyphrases
  • cerebrospinal fluid
  • case control
  • copy number
  • loop mediated isothermal amplification
  • dna methylation
  • label free
  • circulating tumor
  • circulating tumor cells
  • anaerobic digestion
  • childhood cancer