White Matter Abnormalities Track Disease Progression in Multiple System Atrophy.
Sheelakumari RaghavanTimothy G LesnickAnna M CastilloRobert I ReidAngela J FoughtKaely B ThostensonKohl L Johnson SparrmanTonette L GehrkingJade A GehrkingDavid M SlettenPhillip A LowWolfgang SingerPrashanthi VemuriPublished in: Movement disorders clinical practice (2024)
WM abnormalities are core features of MSA disease progression and advance at similar rates in clinical MSA subtypes. Multimodal MRI imaging reveals novel insights into the distribution and pattern of brain abnormalities and their progression in MSA. Selected structural and diffusion measures may be useful for tracking disease progression in MSA clinical trials.