Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.

Samuel N LockhartSuzanne L BakerNobuyuki OkamuraKatsutoshi FurukawaAiko IshikiShozo FurumotoManabu TashiroKazuhiko YanaiHiroyuki AraiYukitsuka KudoRyuichi HaradaNaoki TomitaKotaro HiraokaShoichi WatanukiWilliam J Jagust

Published in: PloS one (2016)

We examined THK5351, a new PET tracer for measuring tau accumulation, and compared multiple analysis methods for quantifying regional tracer uptake. SUVR 40-60 min performed optimally when examining 20 min SUVR windows, and appears to be a practical method for quantifying relative regional tracer retention. The results of this study offer clinical potential, given the usefulness of THK5351-PET as a biomarker of tau pathology in aging and disease.

Keyphrases

positron emission tomography
pet imaging
computed tomography
pet ct
end stage renal disease
cerebrospinal fluid
ejection fraction
cognitive decline
chronic kidney disease
newly diagnosed
peritoneal dialysis
physical activity
prognostic factors
patient reported outcomes
mild cognitive impairment
data analysis