Login / Signup

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.

Samuel N LockhartSuzanne L BakerNobuyuki OkamuraKatsutoshi FurukawaAiko IshikiShozo FurumotoManabu TashiroKazuhiko YanaiHiroyuki AraiYukitsuka KudoRyuichi HaradaNaoki TomitaKotaro HiraokaShoichi WatanukiWilliam J Jagust
Published in: PloS one (2016)
We examined THK5351, a new PET tracer for measuring tau accumulation, and compared multiple analysis methods for quantifying regional tracer uptake. SUVR 40-60 min performed optimally when examining 20 min SUVR windows, and appears to be a practical method for quantifying relative regional tracer retention. The results of this study offer clinical potential, given the usefulness of THK5351-PET as a biomarker of tau pathology in aging and disease.
Keyphrases