miR-34a/BCL-2 signaling axis contributes to apoptosis in MPP+ -induced SH-SY5Y cells.

Zahra ShanesazzadeMaryam PeymaniKamran GhaediMohammad Hossein Nasr Esfahani

Published in: Molecular genetics & genomic medicine (2018)

miR-34a and its target gene, BCL-2, play a possible role in the induction of apoptosis in DA neurons, and therefore, they have a potential role in the pathogenesis of PD. Consequently, the therapeutic potential of miR-34a could be considered in order to inhibit the progression of PD.

Keyphrases

cell cycle arrest
cell proliferation
long non coding rna
long noncoding rna
endoplasmic reticulum stress
cell death
induced apoptosis
oxidative stress
pi k akt
spinal cord
high glucose
copy number
spinal cord injury
signaling pathway
stress induced