Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction.
Rachele PandolfiBianca BarreiraEnrique MorenoVictor Lara-AcedoDaniel Morales-CanoAndrea Martínez-RamasBeatriz de Olaiz NavarroRaquel HerreroJosé Ángel LorenteÁngel CogolludoFrancisco Pérez-VizcaínoLaura MorenoPublished in: Thorax (2016)
Our data indicate that aSMase and IL-6 are not simply biomarkers of poor outcomes but pathogenic mediators of pulmonary vascular dysfunction in ARDS secondary to Gram-negative infections.
Keyphrases
- gram negative
- multidrug resistant
- pulmonary hypertension
- oxidative stress
- diabetic rats
- high glucose
- acute respiratory distress syndrome
- electronic health record
- extracorporeal membrane oxygenation
- big data
- mechanical ventilation
- type diabetes
- drug induced
- endothelial cells
- metabolic syndrome
- intensive care unit
- adipose tissue
- machine learning
- insulin resistance
- glycemic control
- stress induced