Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients.
Mailton Prestes MadrugaLucas Kich GrunLetícya Simone Melo Dos SantosFrederico Orlando FriedrichDouglas Bitencourt AntunesMarcella Elesbão Fogaça RochaPedro Luis SilvaGilson P DornelesPaula Coelho TeixeiraTiago Franco OliveiraPedro R T RomãoLucas SantosJosé Claudio Fonseca MoreiraVinicius Schenk MichaelsenMarcelo CypelMarcos Otávio Brum AntunesMarcus Herbert JonesFlorencia María Barbé-TuanaMoisés Evandro BauerPublished in: Immunity & ageing : I & A (2024)
These findings suggest that dysregulated immune cells, microbial translocation, and T-cell senescence may partially explain the increased vulnerability to COVID-19 in subjects with excess of body weight.