The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.

Martha FoltynAnna-Luisa LugerNadja I LorenzBenedikt SauerMichel MittelbronnPatrick N HarterJoachim P SteinbachMichael W Ronellenfitsch

Published in: British journal of cancer (2019)

We identified DDIT4 as a cell-intrinsic regulator for adaptive responses and therapy resistance in glioblastoma cells which may interfere with cell death induction by temozolomide, radiotherapy or hypoxia by inhibiting mTORC1 activity.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
cell therapy
single cell
radiation therapy
cell proliferation
squamous cell carcinoma
transcription factor
stem cells
locally advanced
mesenchymal stem cells
bone marrow