Treatment of Coronavirus Disease 2019 Patients With Prolonged Postsymptomatic Viral Shedding With Leflunomide: A Single-center Randomized Controlled Clinical Trial.
Mengmei WangYang ZhaoWeihua HuDong ZhaoYunting ZhangTao WangZhishui ZhengXiaochen LiShaolin ZengZhenlian LiuLi LuZhihui WanKe HuPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN-α-2a beyond IFN-α-2a alone.