Stem cell exosome-loaded Gelfoam improves locomotor dysfunction and neuropathic pain in a rat model of spinal cord injury.

Raju PoongodiTao-Hsiang YangYa-Hsien HuangKuender D YangHong-Zhao ChenTsuei-Yu ChuTao-Yeuan WangHsin-Chieh LinJen-Kun Cheng

Published in: Stem cell research & therapy (2024)

Implantation of HucMSCs-EX-encapsulated Gelfoam improves SCI-induced motor dysfunction and neuropathic pain, possibly through its capabilities in nerve regeneration, remyelination, anti-inflammation, and anti-apoptosis. Overall, exosomes could serve as a promising therapeutic alternative for SCI treatment.

Keyphrases

neuropathic pain
spinal cord injury
stem cells
oxidative stress
diabetic rats
spinal cord
drug delivery
mesenchymal stem cells
endoplasmic reticulum stress
high glucose
wound healing
cell death
drug induced
endothelial cells
peripheral nerve