NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells.

Brwa Ali Hussein Linnea KristensonSilvia PesceAnne WöhrYarong TianAlexander HallnerMats BruneKristoffer HellstrandKa-Wei TangElin Bernson Fredrik Bergh Thorén

Published in: Journal for immunotherapy of cancer (2023)

The study results imply that a dimorphism in the NKG2A gene is associated with enhanced NK cell effector function and improved outcome of IL-2-based immunotherapy in AML.

Keyphrases

nk cells
acute myeloid leukemia
copy number
genome wide
genome wide identification
allogeneic hematopoietic stem cell transplantation
dendritic cells
dna methylation
genome wide analysis
natural killer cells