Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage.

Jie ZhangMingxing XueJiefang HuangShan HeLingqiao ZhuXiaonan ZhaoBei WangTingwang JiangYanyun ZhangChanghong MiaoGuoqiang Zhou

Published in: Journal of translational medicine (2024)

UCHL1 plays significant roles in decidualization and dNKs modulation during pregnancy in both humans and mice. Its deficiency indicates a poor pregnancy outcome due to defective decidualization, making UCHL1 a potential target for the diagnosis and treatment of miscarriage.

Keyphrases

replacement therapy
preterm birth
high fat diet induced
pregnancy outcomes
pregnant women
human health
adipose tissue
wild type