CTLA-4 and HLA-DQ are key molecules in the regulation of mDC-mediated cellular immunity by Tregs in severe aplastic anemia.

Bingnan LiuYuanyuan ShaoXiaowei LiangDan LuLi YanAlexey V ChurovRong Fu

Published in: Journal of clinical laboratory analysis (2020)

CTLA-4/HLA-DQ may be key in the regulation of Tregs on mDCs in SAA patients. Our findings should be helpful for further investigation of the mechanism of immune pathogenesis in SAA patients. Studies on the regulators of Treg and CTLA-4 activity will be valuable for SAA therapeutic target research and disease monitoring.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
patient reported outcomes
early onset
celiac disease
iron deficiency