Evaluation of trauma-induced coagulopathy in the fibrinogen in the initial resuscitation of severe trauma trial.

Henry T PengBarto NascimentoShawn G RhindLuis Teodoro da LuzAndrew Beckett

Published in: Transfusion (2021)

About 19%-30% of the trauma patients in the FiiRST trial were coagulopathic on hospital admission depending on the definition of TIC. Analyses of the TIC biomarkers demonstrated that hemostasis would not return to normal after 48-h hospitalization, and fibrinogen replacement improved hypofibrinogenemia.

Keyphrases

trauma patients
phase iii
study protocol
obsessive compulsive disorder
phase ii
clinical trial
cardiac arrest
emergency department
high glucose
drug induced
diabetic rats
early onset
open label
oxidative stress
acute care
adverse drug
electronic health record