I 2 /DMSO-mediated oxidative C-C and C-heteroatom bond formation: a sustainable approach to chemical synthesis.

The I 2 /DMSO pair has emerged as a versatile, efficient, practical, and eco-friendly catalyst system, playing a significant role as a mild oxidative system, and thus employed as a good alternative to metal catalysts in synthetic chemistry. Presently, I 2 /DMSO is a thriving catalytic system that is used in preparing C-C and C-X (X = O/S/N/Se/Cl/Br) bonds, resulting in the formation of various bioactive molecules. Many processes utilize this system, including in situ glyoxal synthesis by diverse sp, sp 2 , and sp 3 functionalities via iodination and subsequent Kornblum oxidation. Focusing on oxidation processes, this study examines the synergistic effect of dimethyl sulfoxide (DMSO) and molecular iodine in improving synthetic techniques. We provide a comprehensive overview of the research progress on the I 2 /DMSO catalytic system for the formation of C-C and C-heteroatom bonds from 2018 to the present. Additionally, the future prospects of this research field are discussed.