Population pharmacokinetics of nadroparin for thromboprophylaxis in COVID-19 ICU patients.

In our study, clearance of nadroparin is associated with an increase in inflammation parameters, use of corticosteroids, vasopression, and renal clearance in critically ill patients. Furthermore, of the simulated regimens, targeted anti-Xa levels were most adequately achieved with a dosing regimen of 5700IU BID. Future studies are needed to elucidate the underlying mechanisms of found covariate relationships.