Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model.

Connor M WanderYa-Dong LiHechen BaoBrent AsricanYan-Jia LuoHeather A SullivanTzu-Hao Harry ChaoWei-Ting ZhangSamantha L ChéryDalton S TartZe-Ka ChenYen-Yu Ian ShihIan R WickershamTodd J CohenJuan Song

Published in: Journal of translational medicine (2023)

We report the structural and functional remodeling of the MS-DG GABAergic circuit during disease progression in 3xTg-AD mice. Dynamic MS-DG GABAergic circuit remodeling represents a compensatory mechanism to combat DG interneuron hyperactivity induced by reduced GABA transmission.

Keyphrases

mouse model
mass spectrometry
multiple sclerosis
ms ms
high fat diet induced
insulin resistance
skeletal muscle
adipose tissue
blood brain barrier