AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth.
Hye Jin YunMin LiDong GuoSo Mi JeonSu Hwan ParkJe Sun LimSu Bin LeeRui LiuLinyong DuSeok-Ho KimTae Hwan ShinSeong-Il EyunYun-Yong ParkZhimin LuJong-Ho LeePublished in: Journal of experimental & clinical cancer research : CR (2023)
Our findings reveal that metabolic stress-enhanced glucose-derived de novo serine biosynthesis is a critical metabolic feature of GBM cells, and highlight the potential to target SSP for treating human GBM.
Keyphrases
- endothelial cells
- protein kinase
- induced apoptosis
- blood glucose
- cell cycle arrest
- cell wall
- machine learning
- skeletal muscle
- genome wide
- induced pluripotent stem cells
- type diabetes
- cell death
- endoplasmic reticulum stress
- cell proliferation
- gene expression
- blood pressure
- stress induced
- dna methylation
- risk assessment
- metabolic syndrome