TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma.
Jasmin KrugAlexander KieferJulia KoelleTytti VuorinenParaskevi XepapadakiBarbara StanicMircea T ChiriacMübeccel AkdisTheodor ZimmermannPapadopoulos G NikolaosSusetta FinottoPublished in: The European respiratory journal (2021)
In PBMCs from pre-school age children, IFN-αR mRNA was reduced and IFN-λR1 mRNA was induced upon treatment with the TLR7/8 agonist R848, thus suggesting new avenues for induction of antiviral immune responses in paediatric asthma.