Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure.
Barry A BorlaugJohn BlairMartin W BergmannHeiko BuggerDaniel BurkhoffLeonhard BruchDavid S CelermajerBrian Lee ClaggettJohn G F ClelandDonald E CutlipIra DauberJean-Christophe EicherQi GaoThomas M GorterFinn GustafssonChristopher Simon HaywardJan van der HeydenGerd HasenfußScott L HummelDavid M KayeJan KomtebeddeJoseph M MassaroJeremy A MazurekScott C McKenzieShamir R MehtaMark Colquhoun PetrieMarco C PostAjith NairAndreas J RiethFrank E SilvestryScott D SolomonJean-Noël TrochuDirk J Van VeldhuisenRalf WestenfeldMartin B LeonSanjiv J Shahnull nullPublished in: Circulation (2022)
In patients with heart failure with preserved or mildly reduced ejection fraction, the presence of latent PVD uncovered by invasive hemodynamic exercise testing identifies patients who may worsen with atrial shunt therapy, whereas those without latent PVD may benefit.