Synthesis of Atropisomers with Biaryl and Vinylaryl Chirality via Pd-Catalyzed Point-to-Axial Chirality Transfer Ring-Opening Reaction.

A palladium-catalyzed domino cyclization/ring-opening reaction between 8 H -indeno[1,2- c ]thiophen-8-ols and N -(2-bromophenyl)propiolamide derivatives is reported. The reaction features a highly stereospecific point chirality to axial chirality transfer process, which enables the synthesis of molecules containing two chiral axes from the compounds with only one stereogenic center.