Plasma lipid profiling of tissue-specific insulin resistance in human obesity.
Birgitta W van der KolkNicole VogelzangsJohan W E JockenArmand ValsesiaThomas HankemeierArnie AstrupWim H M SarisIlja C W ArtsMarleen M J van GreevenbroekEllen E Blaaknull nullPublished in: International journal of obesity (2005) (2018)
In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.