PET imaging during hypoglycaemia to study adipose tissue metabolism.
Marti BossHanne M M RooijackersMijke BuitingaMarcel J R JanssenAnne I J ArensLioe-Fee de Geus-OeiLiesbeth P SalmBastiaan E de GalanMartin GotthardtPublished in: European journal of clinical investigation (2019)
The present findings indicate that [18 F]FDG PET/CT during a hypoglycaemic clamp provides a promising new research tool to evaluate adipose tissue glucose metabolism. Using this method, we observed a specific impairment in visceral adipose tissue [18 F]FDG uptake in type 2 diabetes, suggesting a previously underestimated role for adipose tissue glucose handling in type 2 diabetes.