Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability.

Aglaya G IyevlevaSvetlana N AleksakhinaAnna P SokolenkoSofia V BaskinaAigul R VeninaElena I AnisimovaIlya V BizinAlexandr O IvantsovYana V BelyshevaAlexandra P ChernyakovaAlexandr V TogoEvgeny N Imyanitov

Published in: Breast cancer research and treatment (2022)

Somatic loss of the wild-type CHEK2 allele is observed in approximately half of CHEK2-driven BCs. Tumors without CHEK2 LOH are chromosomally stable. BCs with LOH demonstrate some signs of chromosomal instability; however, its degree is significantly lower as compared to BRCA1/2-associated cancers.

Keyphrases

copy number
wild type
gene expression
genome wide
dna methylation
young adults